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But an inspector wrote that Strive produced “large amounts of odd strengths/doses in anticipation of prescriptions.” They also wrote that different providers whose prescriptions were fulfilled by Strive used identical language to justify the compounding of what regulators described as “essential copies” of commercially available, FDA-approved GLP-1 drugs

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Phase 2 trial results, published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023), demonstrated that participants receiving the highest dose of retatrutide lost an average of approximately 24% of their body weight over 48 weeks — a finding that attracted considerable attention from the medical and scientific communities